Lily Restusari; Helmi Arifin; Dachriyanus; & Yori Yuliandra
The aim of this study was to know the water fraction effect of Salam Leaves (Syzygium polyanthum Wight.Walp) on rats, which would be focused on the effect in lowering uric acid levels in blood on male hyperuricemic-diabetic rats. Material used in this research were n-hexane fraction, ethyl acetate fraction and water fraction of the leaves. Hyperuricemic rats were obtained by giving 3%b/b cow liver homogenates given orally for 15 days in the dose of 200 mg/kg for each rats. The water fraction was given orally for 15 days in the doses of 50; 200 and 250 mg/kg. The blood uric acid levels were measured by Easy Touch® GCU Multi Functions Monitor System (analyzer). The decreasing data of uric acid levels were analyzed by two-way ANOVA and Duncan’s Multiple Range Test. The result of this study showed that water fraction decreased uric acid levels better than n-hexane and ethyl acetate fraction. Uric acid levels were influenced by the dose and the duration of Salam leaves fraction treatment (p < 0.05). The percentage of uric acid levels decrease was influenced by the interaction between dose and duration of treatment (p < 0.05). The water fraction dose given to hyperuricemic-diabetic rats influenced the percentage decrease of uric acid levels. Pathological condition of male hyperuricemic-diabetic decrease the activity of Salam leaves water fraction to lower uric acid levels, hence the adjustment of doses is needed for hyperuricemic-diabetic rats.
Keywords: Syzygium polyanthum, hyperuricemia, diabetic, uric acid
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