A study on the protection effect of methyl gallate (MG) isolated from Toona sureni leaves against atherosclerosis has been carried out. Rats with high blood cholesterol level were obtained by feeding with high fat diet and inducing propyl thiouracil (PTU). MG was administered orally at the doses of 5, 10, and 20 mg/kg. Histopathologic examination was conducted to measure the aortic wall thickness (AWT) and to observe any improvement of endothelial layer. The study showed that MG at doses of 5 and 10 mg/kg exhibited protection against the atherosclerosis indicated by its ability to prevent the thickening of aortic wall and damage of endothelial layer. This study concludes that MG isolated from Toona sureni leaves exhibits a protective effect against atherosclerosis in hypercholesterolemic rats.
Pubslihed in: Research Journal of Pharmaceutical, Biological and Chemical Sciences | Volume 7, Issue 4, page 870-875 | Jul-Aug 2016
Original page: rjpbcs.com
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