Blood Sugar Lowering Effectiveness of Cassytha filiformis Fractions on Diabetic Mice

Blood sugar lowering effect of Cassytha filiformis fractions on alloxan induced diabetic mice has been conducted. A number of 45 male mice with the fasting blood glucose level of ≥126 mg/dL (weighing of 20-30 g and aged of 2-3 months) were divided such where they were treated with Butanol (BuOH), ethyl acetate (EtOAc) and water fractions of Cassytha filiformis at dose of 10 mg/kg for 1, 3 and 7 days respectively. As comparison, a goup of Glibenclamide and vehicle were used. Blood glucose level of the animal was measured before and one day after each last dose. Data was analyzed using Two Way ANOVA followed by Duncan Multiple Range T-Test and the significant was taken at 95% confidence interval. Results showed that the blood glucose level of water, BuOH and EtOAc fractions treated rats were significantly (p<0.05) decreased by 18.2±9.33; 78.6 ±10.1 and 25.2 ±9.33 % respectively, compared to 28.2 ±9.3 % of glibenclamide treated rat, while blood glucose of vehicle treated rat was increased by 33.7 ±9.3 %. Blood glucose lowering effect of C. filiformis was increases by duration of administration (p<0.05) with the average % decrease of blood glucose after 1, 3 and 7 days fractions treatment were -3.5±7.2; 23.0 ±7.2 and 51.5 ±7.6, respectively. These indicated that all fractions of Cassytha filiformis produced blood glucose lowering effect where BuOH fraction is the most potent followed by EtOAc and water fractions. Effect of water and EtOAc fractions was equal to that of glibenclamide while BuOH was much better.

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Pubslihed in: Research Journal of Pharmaceutical, Biological and Chemical Sciences | Volume 7, Issue 6, page 1142-1147 | Nov-Dec 2016

Original page: rjpbcs.com