Reversible Hepatotoxicity of Cassytha filiformis Extract: Experimental Study on Liver Function and Propofol-Induced Sleep in Mice
- At January 20, 2019
- By Yori Yuliandra
- In Scientific Paper
51

Yori Yuliandra, Armenia Armenia*, Rahmad Arief, Mifta Hul Jannah, Helmi Arifin
Abstract
Objective: To study the liver toxicity of Cassytha filiformis L. extract and its reversibility in mice. Methods: A total of 108 male mice were used to investigate the hepatotoxicity of Cassytha filiformis extract (CFE) and the reversibility of its toxicity to the liver. Seventy-two mice were treated with CFE orally for 7 consecutive days. A half of these animals were used to study the sleep time on propofol-induced sleep that comprised the sleep onset time (SOT) and duration of sleep (DOS), while another half was used for the quantitation of serum alanine transaminase (ALT) activity. To investigate the reversibility of the liver toxicity, thirty-six mice were treated with daily CFE for 7 days. Activities of ALT and alkaline phosphatase (ALP) were determined and the liver weight ratio was measured on day 0, 1, 3 and 7 after the termination of the CFE treatment. Data of liver toxicity determination were analyzed by two-way ANOVA followed by Duncan’s multiple range test, while data of the reversibility was analyzed by Pearson’s correlation. The significance level was taken at 95% of confidence interval. Results: CFE shortened the SOT and prolonged the DOS significantly compared with control (p<0.05). The activity of ALT was increased due to the toxicity of CFE. However, the ALT/ALP activities decreased and liver weight ratio increased gradually after the extract treatment was discontinued. The trend of these data was correlated significantly (p<0.05). Conclusion: Cassytha filiformis L. extract is toxic to the liver but the toxicity is reversible depending on doses.
Full paper
Published in: Pharmacognosy Journal, Vol 11, Issue 1, Jan-Feb, 2019, pp.69-74
DOI: 10.5530/pj.2019.1.13
- ITalk Episode 2: Belajar di Negeri Kangguru dengan Beasiswa - April 20, 2021
- Solid Dispersions of Famotidine: Physicochemical Properties and In Vivo Comparative Study on the Inhibition of Hyperacidity - August 9, 2020
- Menjadi “orang kimia” itu… (Refleksi satu tahun penelitian kimia farmasi) - March 7, 2020
Gwzsze
order lasuna pill – how to get lasuna without a prescription himcolin tablets
Mcrwkd
cheap neurontin tablets – order ibuprofen 600mg online cheap oral sulfasalazine
Gnzlqf
buy besivance sale – buy sildamax tablets buy sildamax for sale
Adcykb
generic probenecid 500 mg – order probenecid 500mg generic purchase carbamazepine sale
Cnyhez
celebrex 200mg uk – buy celecoxib 200mg generic purchase indomethacin pills
Btvaqu
order mebeverine 135 mg generic – how to get cilostazol without a prescription pletal 100mg uk
Vttsug
diclofenac 50mg brand – aspirin 75 mg uk aspirin medication
Vqbden
buy mestinon 60 mg pills – cheap mestinon brand imuran 50mg
Wvcqhk
rumalaya order – buy generic shallaki buy generic endep 10mg
Cvkeuu
buy baclofen 10mg generic – buy baclofen 10mg online brand piroxicam
Tlqlso
buy voveran no prescription – buy isosorbide 20mg buy nimotop medication
Ejoeto
cyproheptadine online order – order tizanidine pills tizanidine 2mg ca
Uytfye
mobic 7.5mg pill – purchase mobic without prescription purchase toradol without prescription
Sozpti
buy cefdinir 300 mg online – order omnicef 300 mg sale buy cleocin online
Vzrcjj
order artane – purchase artane generic diclofenac gel order online
Qwgfvy
deltasone 40mg brand – omnacortil 40mg pill buy permethrin online cheap
Tncrxz
buy accutane 10mg generic – buy isotretinoin 40mg for sale deltasone 10mg for sale
Dpfauc
buy permethrin no prescription – retin order retin cost
Ujaeay
betamethasone online order – purchase betnovate online cheap purchase benoquin for sale
Pucdyk
order metronidazole pill – flagyl oral purchase cenforce online
Ndnfjb
buy amoxiclav online – synthroid online buy levothroid pill
Ssfead
buy hyzaar tablets – keflex 500mg usa buy keflex 500mg generic
Uworqz
buy generic clindamycin for sale – buy cheap generic clindamycin indocin 75mg for sale
Fxvowx
order provigil 100mg pills – melatonin 3 mg over the counter order meloset online cheap
Dowwhp
buy crotamiton for sale – purchase aczone pills aczone order
Eeagck
buy zyban 150 mg for sale – order generic bupropion 150 mg buy cheap generic shuddha guggulu
Fkaxsu
xeloda 500 mg drug – cheap naproxen 250mg capsules danocrine
Frkred
order prometrium online – clomiphene 50mg price fertomid brand
Idusea
brand fosamax 70mg – alendronate 35mg price provera 10mg pill
Kqxopr
purchase norethindrone – cheap yasmin generic where can i buy yasmin
Iqmkmv
buy cheap generic yasmin – buy arimidex 1 mg generic arimidex canada
Kqwhvy
cabergoline 0.25mg sale – purchase dostinex sale order alesse for sale
Aanctp
гѓ—гѓ¬гѓ‰гѓ‹гѓі гЃ®иіје…Ґ – г‚ўгѓўг‚г‚·гѓ« гЃ®иіје…Ґ г‚ёг‚№гѓгѓћгѓѓг‚Ї гЃ®иіје…Ґ
Afbusb
バイアグラ е‰ЇдЅњз”Ё – г‚їгѓЂгѓ©гѓ•г‚Јгѓ« гЃ©гЃ“гЃ§иІ·гЃ€г‚‹ г‚·г‚ўгѓЄг‚№ е‰ЇдЅњз”Ё
Xsdfmz
プレドニン処方 – プレドニンジェネリック йЂљиІ© г‚ўг‚ュテイン е‰ЇдЅњз”Ё
Kohcte
eriacta wire – apcalis fit forzest curiosity
Sqxyvp
valif pills ponder – sinemet 20mg usa cost sinemet 20mg
Sqmvjs
valif pills snort – sinemet price cost sinemet
Bbsayg
indinavir buy online – how to purchase diclofenac gel buy emulgel sale
Tgqezd
provigil 100mg without prescription – order duricef 500mg cost epivir
Swrzzm
promethazine 25mg ca – lincocin online order brand lincomycin 500mg
Klzdth
buy prednisone for sale – captopril 25mg ca capoten drug
Mdmjfi
buy generic prednisone 10mg – prednisone 40mg without prescription captopril 25mg oral
Eklbbx
buy accutane paypal – isotretinoin 20mg pills buy zyvox 600 mg sale
Nsbpyb
amoxil without prescription – cheap diovan 80mg combivent 100 mcg usa
Ltylqn
zithromax cheap – tindamax 300mg over the counter nebivolol where to buy
Qnscyw
buy generic omnacortil 20mg – buy generic azipro buy progesterone 200mg generic
Sxdopv
gabapentin pill – buy neurontin 100mg generic itraconazole 100mg tablet
Snwohl
order furosemide 40mg online cheap – piracetam 800 mg price order generic betnovate 20gm
Pofvss
doxycycline online – vibra-tabs oral order glipizide 10mg for sale
Xpvrvg
augmentin 625mg drug – duloxetine 40mg oral duloxetine 20mg uk